Placental Oxidative Stress in the pathogenesis of Hypertensive Disorders of Pregnancy

  • Martin Awe Akilla Department of Medical Laboratory Technology, Bolgatanga Technical University, Bolgatanga
  • Peter Paul Mwinsanga Dapare Department of Biomedical Laboratory Science, School of Allied Health Sciences, University for Development Studies, Tamale, Ghana
  • Eric Misho Bawa Department of Biomedical Laboratory Science, School of Allied Health Sciences, University for Development Studies, Tamale, Ghana
  • Benedict Boateng Antuamwine Department of Biomedical Laboratory Science, School of Allied Health Sciences, University for Development Studies, Tamale, Ghana
  • Ignatius Abowini Nchor Awinibuno Department of Biomedical Laboratory Science, School of Allied Health Sciences, University for Development Studies, Tamale, Ghana
Keywords: Oxidative stress, eclampsia, pregnancy induced hypertension

Abstract

Background: Hypertensive disorders of pregnancy are a major complication of pregnancies and can lead to fetal growth retardation, premature delivery and maternal morbidity and mortality. The study aimed at assessing the potential role of the placenta in the pathogenesis of hypertensive disorders of pregnancy.
Methods: This study was a case-control study conducted at the Upper East Regional Hospital, Ghana from September, 2016 to March 2017.Twenty (20)
pregnant women with hypertensive disorders of pregnancy (i.e., Pregnancy induced hypertension, preeclampsia and eclampsia) as cases and 30 normotensive pregnancies as controls, were included in the study. The placenta was excised after delivery, homogenized and assayed for malondialdehyde,
catalase, total peroxide, oxidative stress index, total antioxidant capacity and placental lipid profile.
Results: The ages of the two groups were similar, with malondialdehyde (p = 0.001) and Oxidative Stress Index (p < 0.001) being significantly higher in the hypertensive group compared to the control group whereas Total Antioxidant Capacity (p < 0.001) and Catalase (p = 0.011) were significantly higher in the control group compared to the hypertensive group. The proportion of normal, term and livebirth deliveries were significantly higher among controls compared to the hypertensive disorders of pregnancy group. Among the estimated oxidative stress markers, total antioxidant capacity turned out to be the best predictor of the hypertensive disorders of pregnancy.
Conclusion: Our findings suggest oxidative stress in women with hypertensive disorders of pregnancy and that placental oxidative stress could be the driving
factor for the pathogenesis and severity of these hypertensive disorders of pregnancy.

Annals of Medical Laboratory Science (2021) 1(2), 39 - 49

References

Bogavac M., Jakovljević A., Stajić§ Z., Nikolić A., Milošević-Tošić M., Dejanović J. and Lozanov-Crvenković Z. (2 01 7) Preeclampsia and level of oxidative stress in the first trimester of pregnancy. Vojnosanit Pregl 74633–638.

Buege J.A. and Aust S.D. (1978) [30] Microsomal lipid peroxidation. Methods in enzymology 52302-310.

Burton G.J. and Jauniaux E. (2011) Oxidative stress. Best Practice & Research. Clinical Obstetrics & Gynaecology 25(3), 287-299.

Ćebović T.N., Marić D., Nikolić A. and NovakovMikić A. (2013) Antioxidant Status in Normal Pregnancy and Preeclampsia upon Multivitamin-Mineral Supplementation in the Region of Vojvodina. International Journal of Bioscience, Biochemistry and Bioinformatics 3(2), 138-144.

Dandana A., Gammoudi I., Ferchichi S., Chahed H., Limam H.B., Addad F. and Miled A. (2011) Correlation of Oxidative Stress Parameters and Inflammatory Markers in Tunisian Coronary Artery Disease Patients. International Journal of Biomedical Science: IJBS 7(1), 6-13.

Das B., Saha-Roy S., Das G.A., Lahiri T.K. and Das H.N. (2012) Assessment of Placental Oxidative Stress in Pre-Eclampsia. The Journal of Obstetrics and Gynecology of India 62(1), 39–42.

Faegheh G., Fatemeh S., Akram R. and Mansour N. (2016) Maternal Parity and Blood Oxidative Stress in Mother and Neonate. Biotech Health Sci. 3(1).

Gyurkovits Z., Hracskó Z., Zimányi M., Varga I.S., Németh G., Pál A. and Orvos H. (2013) Comparison of oxidative stress markers in vaginal deliveries with or without epidural analgesia. Redox Report 18(1), 8-11.

Harma M., Harma M. and Erel O. (2005) Measurement of the total antioxidant response in preeclampsia with a novel automated method. European Journal of Obstetrics & Gynecology and Reproductive Biology 118(1), 47-51.

Hubel C.A. (1999) Oxidative stress in the pathogenesis of preeclampsia. Proc Soc Exp Biol Med 222(3), 222-235.

Jain S., Nair A. and Shrivastava C. (2015) Evaluation of oxidative stress marker Malondialdehyde level in the cord blood of newborn infants. International Journal of Scientific Study 3(6), 73-76

Kintiraki E., Papakatsika S., Kotronis G., Goulis D.G. and K otsis V. (201 5) Pregnancy-Induced hypertension. Hormones (Athens) 14(2), 211-223.

Koracevic D., Koracevic G., Djordjevic V., Andrejevic S. and Cosic V. (2001) Methodfor the measurement of antioxidant activity in human fluids. Journal of clinical pathology 54 (5), 356-361.

Kurlak L.O., Green A., Loughna P. and Broughton Pipkin F. (2014) Oxidative stress markers in hypertensive states of pregnancy: preterm and term disease. Frontiers in Physiology 5310.

Mehendale S., Kilari A., Dangat K., Taralekar V., Mahadik S. and Joshi S. (2008) Fatty acids, antioxidants, and oxidative stress in pre-eclampsia. International Journal of Gynecology & Obstetrics 100(3), 234-238.

Miyazawa T. (1989) Determination of phospholipid hydroperoxides in human blood plasma by a chemiluminescence-HPLC assay. Free Radical Biology and Medicine 7(2), 209-218.

Mohanty S., Sahu P.K., Mandal M.K., Mohapatra P.C. and Panda A. (2006) Evaluation of oxidative stress in pregnancy induced hypertension. Indian Journal of Clinical Biochemistry 101-105.

Montuschi P., Barnes P. and Roberts L.J., 2nd (2007) Insights into oxidative stress: the isoprostanes. Curr Med Chem 14(6), 703-717.

Myatt L. and Cui X. (2004) Oxidative stress in the placenta. Histochemistry and cell biology 122(4), 369-382.

Negre-Salvayre A., Auge N., Ayala V., Basaga H., Boada J., Brenke R., Chapple S., Cohen G., Feher J. and Grune T. (2010) Pathological aspects of lipid peroxidation. Free radical research 44(10), 1125-1171.

Noh E.J., Kim Y.H., Cho M.K., Kim J.W., Kim J.W., Byun Y.J. and Song T.-B. (2014) Comparison of oxidative stress markers in umbilical cord blood after vaginal and cesarean delivery. Obstetrics & Gynecology Science 57(2), 109-114.

Oghagbon S., Agu K., Omorowa F., Okolie N., Okwumabua M. and Omo-Erhabor J. (2016) Oxidative Stress Parameters as Markers of the different Trimesters in Normal Pregnancy. J. Appl. Sci. Environ. Manage. 20 (3), 567-571.

Orhan H., Onderoglu L., Yucel A. and Sahin G. (2003) Circulating biomarkers of oxidative stress in complicated pregnancies. Arch Gynecol Obstet 267(4), 189-195.

Pou K.M., Massaro J.M., Hoffmann U., Vasan R.S., Maurovich-Horvat P., Larson M.G., Keaney J.F., Meigs J.B., Lipinska I. and Kathiresan S. (2007) Visceral and subcutaneous adipose tissue volumes are cross-sectionally related to markers of inflammation and oxidative stress. Circulation 116(11), 1234-1241.

Saczko J., Daczewska M., Marcinkowska A., Chwi£Kowska A., Saczko Z., Ogorza£Ek A. and Banas T. (2002a) Catalase (CT) Activity (SOD) in Placentas Complicated with Pregnancy Induced Hyperternsion (PIH). Zoologica Poloniae 4769-73.

Saczko J., Daczewska M., Marcinkowska A., Chwi£Kowska A., Saczko Z., Ogorza£Ek A. and Banas T. (2002b) Superoxide Dismutase Activity (SOD) in Placentas Complicated with Pregnancy Induced Hyperternsion (PIH). Zoologica Poloniae 4775-80.

Saxena S., Srivastava P.C., Mallick A.K., Das B., Thimmaraju K.V. and Dalmia K. (2016) Comparison of lipid profie and malondialdehyde with severity of blood pressure in pregnancy -induced hypertension. International Journal of Medical Science and Public Health 5(6), 1061-1065.

Sheena S.P. (2012) Comparative study of oxidative stress in pregnancy induced hypertension preeclampsia and eclampsia. International Journal of Biomedical and Advance Research 3 (11).

Shlafer M. and Shepard B.M. (1984) A method to reduce interference by sucrose in the detection of thiobarbituric acid-reactive substances. Analytical biochemistry 137(2), 269-276.

Sravanthi M.J., Sree G.R., Reddy D.P.G. and Subbaiah M.V. (2017) Pregnancy induced hypertension: A prospective study in pregnant women. European Journal of Pharmaceutical and Medical Research 4(12), 393-397.

Yanik M., Erel O. and Kati M. (2004) The relationship between potency of oxidative stress and severity of depression. Acta Neuropsychiatrica 16(4), 200-203.

Yeni E., Gulum M., Selek S., Erel O., Unal D., Verit A. and Savas M. (2005) Comparison of oxidative/antioxidative status of penile corpus cavernosum blood and peripheral venous blood. International journal of impotence research 17(1), 19-22.

Zahoorunnisa D., Swamy P.M.G. and Tembad M.M. (2014) Study of Serum Lipid Profile, Malondialdehyde and Paraoxonase in Normal Pregnant Women and In Pregnant Women with Pre-Eclampsia. International Journal of Pharmacy and Biological Sciences 4 (2), 174-178.
Published
2021-06-20
How to Cite
Akilla, M. A., Dapare, P. P. M., Bawa, E. M., Antuamwine, B. B., & Awinibuno, I. A. N. (2021). Placental Oxidative Stress in the pathogenesis of Hypertensive Disorders of Pregnancy. Annals of Medical Laboratory Science, 1(2), 39-49. https://doi.org/10.51374/annalsmls.2021.1.2.0041
Section
Articles