Hyperglycaemia in newly diagnosed pulmonary tuberculosis patients: a cross-sectional study of the Agona District Hospital
Background: Diabetes mellitus is an important risk factor associated with tuberculosis (TB). This study investigated the prevalence and determinants of
hyperglycemia among newly diagnosed pulmonary tuberculosis patients in the Agona Swedru Municipality.
Method: A hospital-based cross-sectional study was conducted from December 2015 to April 2016. One hundred (100) newly diagnosed pulmonary tuberculosis patients at the Agona Swedru Municipal Hospital (ASMH) were enrolled for the study. Socio-demographic, clinical and anthropometric measurements were collected and fasting blood glucose (FBG) measured using standard protocols. Data was analyzed using Statistical Package for Social Sciences (SPSS) software version 20.0.
Result: Of the 100 participants, 26% had hyperglycemia. The significant factors associated with increased risk of hyperglycemia among participants were history
of diabetes mellitus (OR = 8.17, p= 0.004), severity of infection (OR = 23.64, p < 0.001) and duration of symptoms (OR= 2.63, p= 0.042).
Conclusion: Hyperglycemia was common among newly diagnosed pulmonary tuberculosis patients. History of diabetes mellitus, severity of infection, and
duration of symptoms were the determinants of hyperglycemia in pulmonary tuberculosis. Regular screening of hyperglycemia is essential in the management of tuberculosis. Finally, further studies should be conducted on glucose levels among pulmonary tuberculosis patients using higher sample size to increase the
understanding of the subject.
Annals of Medical Laboratory Science (2021) 1(2), 50 - 58
Asante-Poku A., Asare P., Baddoo N., Forson A., Klevor P., Otchere I. and Gagneux S. (2019) TB-diabetes co-morbidity in Ghana: The importance of Mycobacterium africanum infection. PloS one 14(2), e0211822.
Barham D. and Trinder P. (1972) An improved colour reagent for the determination of blood glucose by the oxidase system. Analyst 97(1151), 142-145.
Del Prato S., Bianchi C. and Marchetti P. (2007) ß‐cell function and anti‐diabetic pharmacotherapy. Diabetes/metabolism research and reviews 23(7), 518-527.
Dooley K.E. and Chaisson R.E. (2009) Tuberculosis and diabetes mellitus: convergence of two epidemics. The Lancet infectious diseases 9(12), 737-746.
Elhadd T.A., Al-Amoudi A.A. and Alzahrani A.S. (2007) Epidemiology, clinical and complications profile of diabetes in Saudi Arabia: a review. Annals of Saudi medicine 27(4), 241.
García-Elorriaga G. and Del Rey-Pineda G. (2014) Type 2 diabetes mellitus as a risk factor for tuberculosis. J Mycobac Dis 4(144), 2161-1068.1000144.
Kibirige D., Ssekitoleko R., Mutebi E. and Worodria W. (2013) Overt diabetes mellitus among newly diagnosed Ugandan tuberculosis patients: a cross sectional study. BMC infectious diseases 13(1), 122.
Niazi A. and Kalra S. (2012) Diabetes and tuberculosis: a review of the role of optimal glycemic control. Journal of Diabetes & Metabolic Disorders 11(1), 28.
Nuttall F. (2015) Body mass index: obesity, BMI, and health: a critical review. Nutrition today 50(3), 117.
Ottmani S., Murray M., Jeon C., Baker M., Kapur A., Lönnroth K. and Harries A. (2010) Consultation meeting on tuberculosis and diabetes mellitus: meeting summary and recommendations [Meeting report]. The international journal of tuberculosis and lung disease 14(12), 1513-1517.
Sen T., Joshi S.R. and Udwadia Z.F. (2009) Tuberculosis and diabetes mellitus: merging epidemics. J Assoc Physicians India 57(5), 399-404.
Shetty N., Shemko M., Vaz M. and D'souza G. (2006) An epidemiological evaluation of risk factors for tuberculosis in South India: a matched case control study. The International Journal of Tuberculosis and Lung Disease 10(1), 80-86.
Viswanathan V., Kumpatla S., Aravindalochanan V., Rajan R., Chinnasamy C., Srinivasan R., Selvam J.M. and Kapur A. (2012) Prevalence of diabetes and pre-diabetes and associated risk factors among tuberculosis patients in India. PloS one 7(7), e41367.
Webb E., Hesseling A., Schaaf H., Gie R., Lombard C., Spitaels A., Delport S., Marais B., Donald K. and Hindmarsh P. (2009) High prevalence of Mycobacterium tuberculosis infection and disease in children and adolescents with type 1 diabetes mellitus. The International Journal of Tuberculosis and Lung Disease 13(7), 868-874.
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